kir3 2  (Alomone Labs)

Journal: Experimental neurology

Article Title: Early postnatal GABAB antagonist treatment normalizes inhibitory/excitatory balance in neonatal Ts65Dn mice, a genetic model of down syndrome.

doi: 10.1016/j.expneurol.2025.115171

Figure Lengend Snippet: Fig. 2. Increased efficiency of GABAB/Girk2 signaling in DG granule cells of neonatal Ts65Dn mice compared to 2N controls. A. Representative whole-cell voltage-clamp recordings from 2N and Ts65Dn granule cells showing neuronal input resistance before (black traces) and during (gray traces) bac lofen application. Voltage steps (−10 mV for 500 ms) were applied from a holding potential of −70 mV, and input resistance was calculated using Ohm’s law. B. Changes in normalized input resistance in 2N and Ts65Dn neurons during baclofen application. C. Quantification of the data showing that the reduction in input resistance induced by baclofen was significantly greater in neurons from Ts65Dn pups (n = 4 neurons,4 mice) compared to 2N pups (n = 7 neurons, 5 mice). Data are presented as mean ± SD. *P < 0.05 (Student’s t-test).

Article Snippet: Membranes were then incubated overnight at 4 ◦C with the primary rabbit polyclonal anti-Girk2 antibody (1:1′000, Alomone Labs, Cat # APC-006, Lot # APC006AN2025).

Techniques:

Journal: NPJ Parkinson's Disease

Article Title: Calbindin and Girk2/Aldh1a1 define resilient vs vulnerable dopaminergic neurons in a primate Parkinson’s disease model

doi: 10.1038/s41531-024-00777-0

Figure Lengend Snippet: List of antibodies

Article Snippet: Rabbit anti G-protein-activated inward rectifying potassium type 2 , 1:400 , Alomone Labs , APC-006 , AB_2040115.

Techniques: Plasmid Preparation